A scientific review funded by Canopy Growth and Charlotte's Web has put forward 160mg as the recommended maximum daily CBD intake for adults without underlying health conditions.
Drawing on data from 28 human clinical trials as well as animal research, the team assessed how CBD affects the liver and established upper oral dosing thresholds for CBD isolate when taken as a dietary supplement.
A daily dose in the range of 100–160mg was considered generally safe for 'healthy adults' — defined as individuals without a diagnosed medical condition who are not taking any medications.
For people who are trying to conceive, currently pregnant, or breastfeeding, the review recommended a lower maximum of 70mg per day.
The researchers noted that CBD has the potential to elevate liver enzyme levels — which can signal liver stress — but observed this effect only at very high doses or when CBD was taken alongside certain other medications.
An earlier study, supported by 12 major CBD companies, found 'no evidence' of liver toxicity among more than 800 participants consuming an average daily dose of 40–50mg.
Based on liver-related findings from human studies, a 'Potential Acceptable Daily Intake' of 0.43mg per kilogram of body weight was calculated for the broader population, covering children and other groups that may be more sensitive to CBD.
The authors called for CBD dietary supplements to carry "adequate" and "specific labelling" around dosing to allow for "consideration of special populations".
They said the review "meets an urgent need to provide guidance to regulators and other entities seeking to provide recommendations for consumer use based on the currently available data."
They added: "This assessment can be refined as additional data becomes available, in particular, human clinical trials with lower doses of CBD and pre-clinical study data on the potential developmental neurotoxicity of CBD."
To read the review in full, click here.
